The 49ers are 34-27-1 lifetime against the Lions

1950	Lions 24-7 (@Det) 49ers 28-27 (in SF)
1951	49ers 20-10 (@Det) 49ers 21-17 (in SF)
1952	49ers 17-3 (in SF) 49ers 28-0 (@Det)
1953	Lions 24-21 (@Det) Lions 14-10 (in SF)
1954	49ers 37-31 (in SF Lions 48-7 (@Det)
1955	49ers 27-24 (@Det) 49ers 38-21 (in SF)
1956	Lions 20-17 (@Det) Lions 17-13 (in SF)
1957	49ers 35-31 (in SF) Lions 31-10 (@Det) Lions 31-27 (in SF)* *Postseason
1958	49ers 24-21 (in SF) Lions 35-21 (@Det)
1959	49ers 34-13 (@Det) 49ers 33-7 (in SF)
1960	49ers 14-10 (@Det) Lions 24-0 (in SF)
1961	49ers 49-0 (@Det) TIE 20-20 (in SF)
1962	Lions 45-24 (@Det) Lions 38-24 (in SF)
1963	Lions 26-3 (@Det) Lions 45-7 (in SF)
1964	Lions 26-17 (in SF) Lions 24-7 (@Det)
1965	49ers 27-21 (@Det) 49ers 17-14 (in SF)
1966	49ers 27-24 (in SF) 49ers 41-14 (@Det)
1967	Lions 45-3 (in SF)
1968	49ers 14-7 (@Det)
1969	Lions 26-14 (in SF)
1970	Lions 28-7 (@Det)
1971	49ers 31-27 (in SF)
1973	Lions 30-20 (@Det)
1974	Lions 17-13 (@Det)
1975	Lions 28-17 (in SF)
1977	49ers 28-7 (in SF)
1978	Lions 33-14 (@Det)
1980	Lions 17-13 (@Det)
1981	Lions 24-17 (@Det)
1983	49ers 24-23 (in SF) Postseason
1984	49ers 30-27 (@Det)
1985	Lions 23-21 (@Det)
1988	49ers 20-13 (in SF)
1991	49ers 35-3 (in SF)
1992	49ers 24-6 (in SF)
1993	49ers55-17 (@Det)
1994	49ers 27-21 (@Det)
1995	Lions 27-24 (@Det)
1998	49ers 35-13 (in SF)
2001	49ers 21-13 (in SF)
2003	49ers 24-17 (in SF)
2006	49ers 19-13(@Det)
2008	49ers 31-13(in SF)
2009	49ers 20-6(in SF)

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